ばんじきゅうす
there is nothing more that can be done; it's all over
Also written 万事窮す、万事急す、万事キュース、万事きゅうす
Expression
今頃いまごろ彼かれは万事休ばんじきゅうすだ。
It is all up with him by this time.
万事休ばんじきゅうすだ。もうどうしようもない。
It is all over with me. It can't be helped.