Dictionary / Vocabulary / お疲れ
おつかれ
thanks (for coming, helping, etc.); glad you could make it; tiredness; fatigue
Also written 御疲れ
大変お疲れのことと思います。
I appreciate that you are very fatigued.
さぞお疲れでしょう。
I dare say you are tired.
お疲れのようですね。きっと働き過ぎですよ。
You look very tired. You must have been working too hard.