お手上げ

Meaning

1. n
   being done for; giving up; being in a hopeless situation; not knowing what to do; being brought to one's knees; throwing up (one's) hands

Example sentences

• 本当にお手上げだ。

  I'm really up a tree.

• 火災で全てのコンピューターディスクが駄目になってしまった時、会社はもうお手上げの状況だった。

  The company faced a major interruption in business when a fire destroyed their archive of computer hard drives and optical discs.

• まったくお手上げだ。

  Everything's a little crazy right now.